Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections - PubMed
pubmed.ncbi.nlm.nih.gov
These findings suggest a potential association between IgG4 induction by mRNA vaccination and a higher risk of breakthrough infection, warranting further investigation into vaccination strategies to ensure sustained protection.

Conclusions: These findings suggest a potential association between IgG4 induction by mRNA vaccination and a higher risk of breakthrough infection, warranting further investigation into vaccination strategies to ensure sustained protection.