Mass Effect Trilogy. Each game when I initially played had 3-4 careers of 50 hours. This was when one game’s choices affecting another game to this degree was very new so I would be trying many different permutations.
Definitely the case if we include LE later on.
Not sure if soundtrack === score here but I really enjoyed :
Transformers: Dark of the Moon
Pirates of the Caribbean 3
Angels and Demons
Star Trek : Into Darkness